Diboson production at the LHC

These proceedings present an overview of the diboson production cross-section measurements and constraints on anomalous triple-gauge boson couplings performed by the ATLAS and CMS collaborations using proton-proton collisions produced at a centre-of-mass energy of √ s = 8 and 13 TeV at LHC. Results for all combinations of W, Z and γ gauge bosons are presented with emphasis on the new WZ production cross sections measured by ATLAS at √ s = 13 TeV and WW production cross section measured by CMS at √ s = 13 TeV. New constraints on anomalous triple-gauge couplings have been set by both experiments at 8 TeV.Peer Reviewe

Influència dels valors d’eficàcia sobre la condició de guanyador o perdedor en waterpolo femení

Aquest estudi ha perseguit trobar els valors d’eficàcia en els marcs situacionals presents en el waterpolo i analitzar la relació entre aquests i la condició de guanyador o de perdedor. Es van registrar tots els partits femenins del X Campionat del Món, per fer-ne una anàlisi consensuada entre dos especialistes entrenats. S’han avaluat mitjançant coeficients les microsituacions de joc en igualtat numèrica, contraatac, replegament defensiu, desigualtat numèrica temporal simple i penal; se n’han obtingut valors d’eficàcia. Per al tractament estadístic es va realitzar una ANOVA d’un sol factor seguida per la prova de Tukey; s’han revelat diferències significatives en igualtat numèrica amb possessió i sense: en possibilitat (,005), concreció, definició i precisió (,000), resolució (,001) i exactitud (,017). En el contraatac i el replegament defensiu: en possibilitat, concreció, definició, resolució i precisió (,000) i exactitud (,001). En desigualtat numèrica temporal simple amb possessió i sense: en possibilitat (,020), concreció, definició, precisió i exactitud (,000) i resolució amb possessió (,002) i sense possessió (,003); prenent com a referència un valor de p<,05. Hi ha diferències significatives entre la condició de guanyador o perdedor en dotze coeficients d’eficàcia en igualtat numèrica, dotze en transició, dotze en desigualtat numèrica temporal simple i cap en el penal

Influencia de los valores de eficacia sobre la condición de ganador o perdedor en waterpolo femenino

Este estudio ha perseguido hallar los valores de eficacia en los marcos situacionales presentes en el waterpolo y analizar la relación entre éstos y la condición de ganador o perdedor. Se registraron todos los partidos femeninos del X Campeonato del Mundo, para su análisis consensuado entre dos especialistas entrenados. Se han evaluado mediante coeficientes las microsituaciones de juego en igualdad numérica, contraataque, replegamiento defensivo, desigualdad numérica temporal simple y penalti; obteniendo valores de eficacia. Para el tratamiento estadístico se realizó un anova de un solo factor seguido por la prueba de Tukey, revelando diferencias significativas en igualdad numérica con y sin posesión: en posibilidad (,005), concreción, definición y precisión (,000), resolución (,001) y exactitud (,017). En el contraataque y replegamiento defensivo: en posibilidad, concreción, definición, resolución y precisión (,000) y exactitud (,001). En desigualdad numérica temporal simple con y sin posesión: en posibilidad (,020), concreción, definición, precisión y exactitud (,000) y resolución con posesión (,002) y sin posesión (,003); tomando como referencia un valor de p<,05. Existen diferencias significativas entre la condición de ganador o perdedor en doce coeficientes de eficacia en igualdad numérica, doce en transición, doce en desigualdad numérica temporal simple y ninguno en el penalti

Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs)

Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictive tests applied to clinical practice. Determination of lymphocyte radio-sensitivity by radio-induced apoptosis arises as a possible method to predict tissue toxicity due to radiotherapy. The aim of the present study was to analyze radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients and to explore their role in predicting radiation induced toxicity. Seventy nine consecutive patients suffering from head and neck cancer, diagnosed and treated in our institution, were included in the study. Toxicity was evaluated using the Radiation Therapy Oncology Group scale. Peripheral blood lymphocytes were isolated and irradiated at 0, 1, 2 and 8 Gy during 24 hours. Apoptosis was measured by flow cytometry using annexin V/propidium iodide. Lymphocytes were marked with CD45 APC-conjugated monoclonal antibody. Radiation-induced apoptosis increased in order to radiation dose and fitted to a semi logarithmic model defined by two constants: α and β. α, as the origin of the curve in the Y axis determining the percentage of spontaneous cell death, and β, as the slope of the curve determining the percentage of cell death induced at a determined radiation dose, were obtained. β value was statistically associated to normal tissue toxicity in terms of severe xerostomia, as higher levels of apoptosis were observed in patients with low toxicity (p = 0.035; Exp(B) 0.224, I.C.95% (0.060-0.904)). These data agree with our previous results and suggest that it is possible to estimate the radiosensitivity of peripheral blood lymphocytes from patients determining the radiation induced apoptosis with annexin V/propidium iodide staining. β values observed define an individual radiosensitivity profile that could predict late toxicity due to radiotherapy in locally advanced head and neck cancer patients. Anyhow, prospective studies with different cancer types and higher number of patients are needed to validate these results

Prediction of clinical toxicity in localized cervical carcinoma by radio-induced apoptosis study in peripheral blood lymphocytes (PBLs)

<p>Abstract</p> <p>Background</p> <p>Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation is a limiting factor for treatment success. Determination of lymphocyte radiosensitivity by radio-induced apoptosis arises as a possible method for predictive test development. The aim of this study was to analyze radio-induced apoptosis of peripheral blood lymphocytes.</p> <p>Methods</p> <p>Ninety four consecutive patients suffering from cervical carcinoma, diagnosed and treated in our institution, and four healthy controls were included in the study. Toxicity was evaluated using the Lent-Soma scale. Peripheral blood lymphocytes were isolated and irradiated at 0, 1, 2 and 8 Gy during 24, 48 and 72 hours. Apoptosis was measured by flow cytometry using annexin V/propidium iodide to determine early and late apoptosis. Lymphocytes were marked with CD45 APC-conjugated monoclonal antibody.</p> <p>Results</p> <p>Radiation-induced apoptosis (RIA) increased with radiation dose and time of incubation. Data strongly fitted to a semi logarithmic model as follows: RIA = βln(Gy) + α. This mathematical model was defined by two constants: α, is the origin of the curve in the Y axis and determines the percentage of spontaneous cell death and β, is the slope of the curve and determines the percentage of cell death induced at a determined radiation dose (β = ΔRIA/Δln(Gy)). Higher β values (increased rate of RIA at given radiation doses) were observed in patients with low sexual toxicity (Exp(B) = 0.83, C.I. 95% (0.73-0.95), p = 0.007; Exp(B) = 0.88, C.I. 95% (0.82-0.94), p = 0.001; Exp(B) = 0.93, C.I. 95% (0.88-0.99), p = 0.026 for 24, 48 and 72 hours respectively). This relation was also found with rectal (Exp(B) = 0.89, C.I. 95% (0.81-0.98), p = 0.026; Exp(B) = 0.95, C.I. 95% (0.91-0.98), p = 0.013 for 48 and 72 hours respectively) and urinary (Exp(B) = 0.83, C.I. 95% (0.71-0.97), p = 0.021 for 24 hours) toxicity.</p> <p>Conclusion</p> <p>Radiation induced apoptosis at different time points and radiation doses fitted to a semi logarithmic model defined by a mathematical equation that gives an individual value of radiosensitivity and could predict late toxicity due to radiotherapy. Other prospective studies with higher number of patients are needed to validate these results.</p

Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients

<p>Abstract</p> <p>Background</p> <p>DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral blood lymphocytes by flow cytometry analysis has also been proposed as an approach for predicting normal tissue responses following radiotherapy. The aim of the present study was to explore the association between initial DNA damage, estimated by the number of double-strand breaks induced by a given radiation dose, and the radio-induced apoptosis rates observed.</p> <p>Methods</p> <p>Peripheral blood lymphocytes were taken from 26 consecutive patients with locally advanced breast carcinoma. Radiosensitivity of lymphocytes was quantified as the initial number of DNA double-strand breaks induced per Gy and per DNA unit (200 Mbp). Radio-induced apoptosis at 1, 2 and 8 Gy was measured by flow cytometry using annexin V/propidium iodide.</p> <p>Results</p> <p>Radiation-induced apoptosis increased in order to radiation dose and data fitted to a semi logarithmic mathematical model. A positive correlation was found among radio-induced apoptosis values at different radiation doses: 1, 2 and 8 Gy (p < 0.0001 in all cases). Mean DSB/Gy/DNA unit obtained was 1.70 ± 0.83 (range 0.63-4.08; median, 1.46). A statistically significant inverse correlation was found between initial damage to DNA and radio-induced apoptosis at 1 Gy (p = 0.034). A trend toward 2 Gy (p = 0.057) and 8 Gy (p = 0.067) was observed after 24 hours of incubation.</p> <p>Conclusions</p> <p>An inverse association was observed for the first time between these variables, both considered as predictive factors to radiation toxicity.</p